N1ED in a Custom Multisite CMS
A lot of SaaS CMSs and online website builders help a wide audience of people and companies create their own websites.
The main difference between single-website CMSs and multisite CMSs is that the latter manage multiple websites independently, ensuring their preferences, file storages, and custom Bootstrap block templates do not intersect between different users (websites) until you explicitly use block template sharing feature.
So you need to use an individual API key for every website your CMS users have and load the editor (N1ED, TinyMCE+N1ED, or CKEditor+N1ED) with these personal API keys.
Use the Admin API to automate API key management, and configure separate file storages to isolate users in their personal directories.